Dr. Lakshmi C. Mishra
M. Pharm., Ph.D. (Pharmacol.),
BIMS (Ayurveda)
National
Institute of Ayurveda & Toxicology Reviews
Tel. 301 762 82632;
301 537 8804; e- mail:Mishra13505@yahoo.com
www.lcmishra.com, www.aapra.com
Dr.
Lakshmi C. Mishra is President of the National Institute of Ayurveda and Toxicology Reviews in
Dr.
Lakshmi C. Mishra is an Adjunct Professor in the Research
Division and also provided clinical Ayurvedic
services in the SCU health system; provided the first ayurvedic
Health Care in the SCU clinic system. He
has a long work history as a toxicologist for the federal government,
specialized in cancer chemotherapy research in the past, and has turned his
attention to the development of treatment protocols combining Western Science
and Ayurvedic principles.
He
provided the content expertise for the development and implementation of basic
science, cancer chemotherapy and chemo-
prevention using herbal dietary supplements. Dr. L.C. Mishra was PI of
trials using animal models to investigate both Guggul
and another Ayurvedic
herb, Ashwagandha.
He
has an extensive background, both as a scientist and clinician in modern or Ayurvedic medicine and as a bench scientist in cancer
chemotherapy, pharmacology and toxicology, a unique combination of
qualifications indeed. He had been a
reviewer for Alternative Therapies in Health and Medicine (
Dr. Mishra has 23 years of experience in the
field of public health policy and health related safety regulations with
Federal Government agencies. He was the Ex-officio Board Member of the
National Cancer Advisory Board, National Cancer Institute, National Institutes
of Health,
Recently, he edited a book, “Scientific Basis of Ayurvedic Therapies” which has been published by
Scientific Milestones
I. Cancer chemotherapy
1.
Oncogeneic viruses: He demonstrated with Rauscher
virus that oncogneic viruses do not have to be in a
intact particle form and that soluble material in the 80,000g supernatant is
just as potent
as the particulate material in inducing leukemia in mice. The active material is probably a ribonucleoprotein.
Using the supernatant he developed a spontaneous tumor model to test
cancer chemotherapeutic agents and screened many antitumor
agents.
2.
Delayed toxicity: Delayed
toxicity in tumor bearing rats appearing 60 days after the first 2-5 doses of antifolate compounds containing alkylating
moiety was thought for many years to be due to irreversible blockade of folic
acid recepters because rats were showing signs of
folic acid deficiency and dying due to severe anemia. Folinic acid
administration helped but did not reverse the toxicity. Dr. Mishra demonstrated that the fast growing
cells (blast cells) of the teeth were damaged by the initial drug treatment
thus the teeth became weak and broke off in next 60 days. As a consequence the rats could not bite and
eat regular food and died due to starvation. When the rats were given powdered
food by gavage twice a day, all rats showing delayed
toxicity recovered and lived their normal lifespan. His study established the mechanism of the
delayed toxicity.
3.
Rational design of anticancer drugs: He
demonstrated the feasibility of enzyme-dependent lethal synthesis concept to
develop drugs with a high degree of selectivity. He used cancer cells resistant to an antitumor agent, methotrexate
(inhibitor of dihydrofolate reductase
enzyme), containing higher levels of dihydrofolate reductase enzyme
and treated them with dihydrohomofolic acid and
showed that the tetrahydrohomofolic acid formed in
the cells was selectively toxic to cancer cells. This was well documented in
L1210 leukemia tumor bearing mice. A US
patent was granted to National Cancer Institute in 1974 on 5-methyl tetrahydrohomofolate based on Dr. Mishra’s
research; an example of rational drug development where he carried a chemical
molecule to an important anti-cancer drug.
4.
In-vivo enzyme assay: Dr. Mishra has worked extensively with
chromatographic techniques conducting biochemical studies using dihydrofolate reductase and
pioneering the in-vivo bioassay of dihydrofolate reductase enzyme to
determine the enzyme inhibition. He also
developed analytical methods to conduct drug metabolism and tissue distribution
studies on dihydro- and tetrahydrohomofolate.
II. Carcinogenesis and Toxicological
studies
1. Cancer
guidelines: He developed guidelines to
assess carcinogenic potential of chemicals for
2.
Neurotoxicity: He also developed guidelines to assess
carcinogenic potential of chemicals for U.S. Consumer Products Safety
Commission to regulate cancer causing chemicals in consumer products
(1991-92).
3.
Toxicology
and health risk assessment: Dr. Mishra
evaluated over 50 pesticides and many solvents and chemicals for health risk
for US Environmental agency and US Consumer Product Safety commission.
III. Herbalceutical and Complementary/alternative Medicine
Activities
One of the research goals of Dr. Mishra has
been to explore scientific basis for ayurvedic
therapies. He conducted a major review of pharmacological studies on Commiphora mukul an
ayurvedic herbs proven highly effective in musculoskeltal diseases and cholesterol lowering
effects. He further reviewed scientific
data on Withania somnifera
for adaptogenic properties and its use in stress and
mental disorders. In addition, he
initiated the clinical trials and case studies on ayurvedic
therapies for musculoskeletal disease, e.g., osteoarthritis, TMJ, and fibromyelgia. His
extensive literature review on ayurvedic
therapies led him to write a book entitled Scientific Basis of Ayurvedic Therapies, published by
IV.
Professional Presentations and Lectures
Community Lectures/Services
Historical Perspective
of Ayurveda,
Ayurvedic Health Care lecture at
Professional Presentations
1. L.C. Mishra, Ayurvedic
Medical system of India in Textbook of Complementary and Alternative Medicine,
2nd edition , Chon-Su Yuan, E. J. Bieber,
B. A. Bauer, Informa UK Ltd., 2006
2. Vinjamury SP, Singh BB, Mishra LC, Khorsan
R, Comberiati R, Meier M, Holm S. Effectiveness of
pragmatic chiropractic treatment in temporomandibular
disorders (TMD)- A pilot study. ACC Conferenc,
3.. Singh, B.B., Mishra,
L.C., Gandhi S, Khorsan, R., Singh, V.J., Vinjamury, S.P, Kizhakkeveettil,
A. Ayurvedic and Collateral Herbal Treatments of
Liver Diseases: A Systematic Review of Randomized Control Trials (RCTs) and Quasi-Experimental Designs (QEDs),
NAMA Conference, Long Beach, CA.,
10/22/04
4.
Singh, B.B., Mishra, L.C., Vinjamury, S.P, Khorsen, R., Nanjegowda, D., Kubik, E.,
Shepard, N. Effectiveness of Pragmatic Ayurvedic Care
on the Treatment of Osteoarthritis (OA): An Experimental Case Series, WAVE
Conference, Shady Grove, MD., 7/04.
5.
Singh, B.B., Mishra, L.C., Vinjamury, S.P., Aquilina, N.,
Singh, V.J., Shepard, N. The Effectiveness of Commiphora
Mukul for Osteoarthritis (OA) of the Knee: An
Outcomes Study, WAVE Conference, Shady Grove, MD., 7/04.
6.
Singh, B.B., Mishra, L.C., Vinjamury, S.P., Kubik, E.,
Singh, V.J., Shepard, N. Ayurvedic Herbal Treatments
of Hyperlipidemia: A Systematic Review, WAVE
Conference, Shady Grove, MD., 7/04.
7. Mishra, L.C., Singh, B.B. Ayurvedic Therapies of Ama-Vata
(Rheumatoid Arthritis), AAPI Conference, San Diego, CA., 6/04. Mishra, L.C.,
Singh, B.B. Ayurvedic Therapies of Ama-Vata (Rheumatoid Arthritis), AAPI Conference,
8. Mishra, L.C,
Ayurvedic Therapies of Rheumatoid Arthritis, Integrated Medicine Educational Program:
Integrating Ayurveda into Clinical Practice.
9. Singh, B.B., Mishra, L.C., Vinjamury, S., Aquilina, N., Singh,
V., Shepard, N. The Effectiveness of Commiphora Mukul for Osteoarthritis of the Knee: An Outcomes
Study, RAC Conference,
10. Mishra,
L.C, Regular lectures every semester on Ayurveda
to chiropractic students at Southern California University (1998-2003)
11. Mishra, L.C ,Ayurvedic
Therapies at School of Pharmacy USC,
12.Vinjamury, S.P., Singh, B.B., Mishra, L.C. Research Issues in Complementary and Alternative
Medicine. Presented at the World Ayurveda
Congress,
13. Singh, B.B., Mishra, L.C.
Effectiveness of Guggul in Treatment of
Osteoarthritis. Findings
from an Experimental Case Study and an Outcomes Study. Presented to SCU Clinical Faculty, (3/2002).
14.. Singh, B.B., Mishra, L.C.
, Ayurved as an Adjunctive Therapy to Chiropractic
Care: Evidence of Effectiveness in OA. SCUHS Visiting Scholar
Program, (3/2002).
15. Mishra, L.C. ,Ayurvedic
Therapies at
16. Mishra,
L.C. 3rd. Southern Yoga Conference,
17. Mishra,
L.C., Historical Perspective of Ayurveda: Introduction to Ayurvedic
herbs, their purity and analysis.
18. Mishra, L.C. , Scientific
Basis of Ayurvedic Therapies; Chemistry and Use of Guggul,
19. Mishra,
L.C. Continuing Education Program on
Internet:
20. Mishra,
L.C., Introduction to Ayurvedic Concepts of
Illness and Therapy, University of
1987 Associate Contract Management and
Project Supervising Scientists and Engineers from Office of Personnel
Management,
Health Science Administrator/Grants - GS-14 rating from NIH
1983 Introduction to Supervision Course given by
the U.S. Office of Personnel Management
1980
Contract
Management for Project Officers,
1967 Ph.D. in Biochemical Pharmacology;
1959 M. Pharm. (Pharmacognosy of Ayurvedic herbs),
1958 B. Pharm.,
Work Experience
1998, September-
Present, Adjunct Professor
[full], Southern California University of Health Sciences,
-Provide leadership in design and
implementation of
clinical and basic science investigations of commonly used herbal
therapies, and to provide elective
courses to pre-clinical and clinical students when required.
-Provided Ayurvedic
Health Care Services at UHC until April, 2003.
-Provide leadership in publication of
literature on Ayurvedic Medicine.
-Review research manuscripts for peer
reviewed journals. Currently
reviewing manuscripts for Alternative
Therapies in Health and Medicine.
-Filed an RO1 as PI in June, 1999 to
-Advisor to
1997 – present Sequoia Communications & Health
Sciences, Inc,
Provide consultant
services to a variety of food, pharmaceutical, and research organizations in
the area of analytical methods, toxicology, pharmacology and
health risk assessment.
Research
and teaching in Ayurvedic herbal dietary supplements.
1979-
1997 -- Branch Chief.
1986-1997 Senior
Toxicologist - Duties included work on cancer risk assessment from suspect
carcinogens and health risk from neurotoxic
chemicals. Major contribution was developing the guidelines to evaluate cancer
causing chemicals and neurotoxic chemicals (Federal
Register, 57:46626‑‑74, 1992).
1981‑1986 Branch
Chief - Supervised toxicity reviews and provided recommendations to the
Agency concerning health effects of many chemicals. Supervised the work of six
other scientists.
1979-1981
Toxicologist - Duties included work on cancer risk
assessment from suspect carcinogens and health risk from neurotoxic
chemicals.
August 1974 – 1979 Toxicologist -Environmental Protection Agency
Duties included work on pesticide residues in food and
cancer risk assessment from chemical. Published a paper regarding metabolism of pesticides in August
1976. As a Pharmacologist at the U.S.EPA, involvement included
evaluation of pesticide residue in food safety for general toxicity, immunotoxicity, neurotoxicity, mutagenicity, carcinogenicity, and teratogenicity.
Conducted health risk assessment and health review on several
toxic chemicals.
September 1967 – 1974 Toxicoloist- Microbiological Associates,
Duties included work on Cancer chemotherapy under a
contract with the National Cancer Institute. Served as Branch
Chief at Microbiological Associates Inc.,
January 1966 – Sept. 1967 Post Doctoral Fellow. Roswell Park Memorial Institute
Duties
included research work in cancer chemotherapy (antifolates).
June
62 - December 1962
June
1961-June 1962
June
1960- June 1961
Puna,
1954-1959 Private practice of Ayurvedic
Medicine in
Honors
Received
cash merit award in 1992 from the US CPSC
CPSC representative (ex-officio) Board
Member for the National Cancer Advisory Board, National Cancer Institute,
National Institutes of Health, Bethesda, MD, Jan 1981- November 3, 1997.
Society Membership
American Association of
Cancer Research, 1968 to 1985
American Society of
Pharmacology and Experimental Therapeutics, 1967-1985
Editorial
board: Journal of the American Neutraceutical
Association, member,2001
Editorial
Review Panel, Alternative Therapies in Health and Medicine, member,2000.
Media Appearances
·
Interviewed on Adelphia Cable Television Net Work,
· Guest on WETA-Darshan
TV,
Publications:
Herbaceutical
Primarily ( Most recent to oldest Publication date)
·
Scientific Basis
of Ayurvedic Therapies, Mishra, L.C., Editor, CRC Press,
2003
·
Mishra, L.C.,
Health Care and Disease Management in Scientific Basis of Ayurvedic Therapies, Lakshmi
Chandra Mishra, Editor, chapter 2, CRC
Press, 2003
·
Mishra, L.C.,
Rheumatoid Arthritis, Osteoarthritis, and gout in Scientific Basis of Ayurvedic Therapies, Lakshmi
Chandra Mishra, Editor, chapter 10, CRC
Press, 2003
·
Mishra, L.C.,
Allergic Reactions in Scientific
Basis of Ayurvedic Therapies, Lakshmi
Chandra Mishra, Editor, chapter 12, CRC
Press, 2003
·
ahu, M. & Mishra,
L.C., Benign growth, Cysts, and Malignant Tumors in Scientific Basis of Ayurvedic
Therapies, Lakshmi Chandra Mishra, Editor, chapter 16, CRC Press, 2003
·
Vohra, D.S. & Mishra, L.C., Alzheimer’s Disease in Scientific Basis of Ayurvedic
Therapies, Lakshmi Chandra Mishra, Editor, chapter 23, CRC Press, 2003
·
Singh, R.H., Mishra, L.C., Psychiatric
Disorders in Scientific Basis of Ayurvedic Therapies, Lakshmi
Chandra Mishra, Editor, chapter 25, CRC
Press, 2003
·
Mishra, L.C.
& Singh R.H., Parkinsons’s
Disease in Scientific Basis of Ayurvedic Therapies, Lakshmi
Chandra Mishra, Editor, chapter 26, CRC
Press, 2003
·
Gauthaman, K., & Mishra,
L.C., Ischemic Heart Disease in in Scientific Basis of Ayurvedic
Therapies, Lakshmi Chandra Mishra, Editor, chapter 30, CRC Press, 2003
·
Singh, B. B., Mishra, L. C., Vinjamury,
S. P., Aquilina, N., Singh, V. J., Shepard, N., The
effectiveness of Commiphora mukul
for osteoarthritis of the knee: An outcome study. , Alt. Ther.
Health & Med. 9 (3): 74, 02
·
Adams, J., Klaidman, L. K., Mishra,
L. C., Singh, B. B., Effect of Guggul in rat
model of stroke. , Alt. Ther. Health & Med.
8 (4): 20, 02
·
James D. Adams,
Jr., Jun Yang, Lakshmi C. Mishra and Betsy B. Singh. Effects
of Ashwagandha
in a stroke model, Alt. Ther. Health & Med. 8 (5): 18, 02
·
L.C. Mishra, B.B. Singh, and S. Dagenais. Ayurved: Historic
Perspective and Principles of the
Traditional Health Care System of
·
L.C. Mishra, B.B. Singh, and S. Dagenais.
Health Care and Disease Management in
Ayurved. Alt. Ther.
Health & Med. 7(2): 44-50, 2001
·
B.B. Singh, N. Aquilina, L.C.
Mishra, F. Kohlbeck. The Usefulness of Commiphora Mukul for Osteoarthritis of the Knee: An
Experimental Case Study. Alt.
Ther Health & Med. 7(2): 120 & 112-114, 2001
·
B.B. Singh, F. Zarow, L.C. Mishra,
S. Dagenais Acupuncture as a Treatment for
Osteoarthritis of the Knee: Clinical
Relevance. Topics in Clinical
Chiropractic7(2): 1-4, 2000
·
L.C. Mishra,
B.B. Singh, and S. Dagenais. Ayurvedic
Therapies of Arthritis. Topics in Clinical Chiropractic 7(2): 13-16, 2000
·
L.C. Mishra, B.B. Singh.
Scientific Basis for Therapeutic Uses of Guggul
(Commiphora Mukul). Topics in Clinical Chiropractic, 7 (2)
:51-56, 2000
·
L.C. Mishra, B.B. Singh, and S. Dagenais. Scientific Basis for Therapeutic Uses of Ashwagandha (Withania somnifera). Alt. Med. Review, 5 (4): 334-346, 2000
Primarily
Cancer Articles: Oldest to Most recent publication date
·
L.C. Mishra, Phytochemical Investigations on Justicia Gendarusa ( an ayurvedic drug). M. Pharm. Thesis,
·
L. C. Mishra,
Pharmacologic Studies of Some Alkylating Agents. Ph.D., Thesis, State